Research Institute

Position: Qianfoshan Hospital Research InstituteDetail

Introduction to Shandong Institute of Respiratory Diseases/Department of Respiratory and Critical Care Medicine

Introduction to Shandong Institute of Respiratory Diseases/Department of Respiratory and Critical Care Medicine


Shandong Institute of Respiratory Diseases was established in July 2019 and is a provincial-level specialized disease institute approved by the Institutional Preparation Committee of the Shandong Provincial Committee of the Communist Party of China. The Shandong Institute of Respiratory Diseases consists of the Basic Research Institute, the Clinical Respiratory Center and the Shandong Provincial Consultation Center for Difficult and Rare Diseases, which can carry out the diagnosis and treatment of diseases in the respiratory profession and cutting-edge medical scientific research.

As the core Department of Shandong Institute of respiratory diseases, the Department of respiratory and critical care medicine (PCCM) of the First Affiliated Hospital of Shandong First Medical University was founded in 1988. Now it is the regional respiratory medical center of Shandong Province, the key specialty of Shandong Province, the “excellent discipline” of the standardization construction of the national respiratory and critical care medicine department, the national PCCM specialized base, the lung function training base, and the respiratory intervention training base, MICU\RICU training base, the first batch of medical consortia Units of China-Japan Friendship Hospital of national respiratory clinical research center, and the first batch of core units of national respiratory clinical research center. In 2018, it was selected into the National Respiratory System Diagnosis and Treatment Ability Improvement Project Reserve List (only nine respiratory diseases in China).


Professional team

Dong Liang, director of Shandong Institute of respiratory diseases, chief physician, doctor of medicine, doctoral supervisor; leader of medical treatment expert group of Shandong new coronavirus pneumonia epidemic management command; studied in department of molecular biology of Tufts University from November 1996 to December 1997, and further study in department of respiratory and critical care of University of Chicago Medical Center from February 2008 to February 2010; mainly engaged in the diagnosis and treatment of bronchial asthma, chronic obstructive pulmonary disease, lung tumors, and the rescue and treatment of critical illness; as the first author or the corresponding author published 52 papers in international professional journals (SCI-indexed journals); undertook three general projects of the National Natural Science Foundation of China, one national key research and development plan, and two key research and development plans of Shandong Province; served as a judge of the National Natural Science Foundation of China; member of the editorial board of Journal of Respiration, Shandong University Journal Medical Edition, International Journal of Respiration, and Chinese Edition of CHEST.

The department has a strong lineup of medical professionals, a reasonable echelon structure, clear professional direction and strong technical strength. There are 37 physicians, including 1 specially-appointed expert, 8 chief physicians, 11 associate chief physicians, 16 attending physicians, 17 doctors and 20 masters.

At the same time, the Department of Respiratory and Critical Care Medicine also has an excellent nursing team with a solid style. They are patient, meticulous and full of vigor. There are 79 nursing staff, including 1 deputy chief nurse, 16 supervisor nurses, 42 senior nurses and 20 nurses. They are responsible for nursing care of patients with respiratory diseases and critically ill patients.


Medical unit configuration

The Department of Respiratory and Critical Care Medicine has four nursing units: two respiratory specialist wards, one respiratory healthcare specialist ward, and one RICU. At present, there are 120 beds, including 80 beds in the respiratory specialist ward, 25 beds in the respiratory health care specialist, and 15 in the RICU.

Specialist wards have clear division of professional directions, and there are nine sub-specialties of lung cancer, infection, asthma, interstitial lung disease, chronic obstructive pulmonary disease, pulmonary embolism and pulmonary vascular disease, sleep disordered breathing disease, pulmonary rehabilitation, and respiratory critical illness. .

In addition to the specialist ward, the subject also has a respiratory endoscopy diagnosis and treatment center, a respiratory disease clinical research platform, a lung function diagnosis and treatment room, a breathing and sleep diagnosis and treatment room, and a comprehensive respiratory clinic. The clinic has eight specialized clinics for asthma, chronic obstructive pulmonary disease, pulmonary infection, interstitial lung disease, pulmonary nodules, smoking cessation, breathing and sleep disorders, and allergies, as well as a comprehensive clinic for outpatients, respiratory specialist clinics, well-known specialist clinics and Consultation center for difficult and rare respiratory diseases.



PCCM is equipped with an independent RICU, which is a relatively independent medical unit and an important part of respiratory and critical care medicine. The department is equipped with cutting-edge medical equipment, including Drager column tower, 15 sets of central monitoring system, several invasive and non-invasive ventilators, ECG monitors, multi-functional defibrillators, bedside blood gas analyzers, micro pumps, etc.

The department is characterized by the treatment of respiratory critical illnesses, and is especially good at the comprehensive treatment of typical diseases such as acute respiratory failure (including acute respiratory distress syndrome), septic shock, sepsis, and pulmonary embolism. The daily work of our department and the general ward of the respiratory department are closely integrated and connected in an orderly manner, which provides a solid guarantee for the effective treatment of critically ill patients. The discipline has advanced technology in organ function support represented by mechanical ventilation, and has carried out non-invasive/invasive respiratory support, high-flow nasal oxygen therapy, non-invasive/invasive hemodynamic monitoring, external diaphragm pacing, bedside ultrasound diagnosis , Bedside blood purification, aortic balloon counterpulsation, extracorporeal membrane oxygenation (ECMO) technology and other important organ support technologies, providing critical patients with comprehensive monitoring and support of vital organ functions such as breathing and circulation, focusing on advantages and the ability to diagnose and treat special diseases radiates to surrounding provinces, drives the overall improvement of the critical care level in the region, and builds a multidisciplinary collaboration platform.


Respiratory endoscopy center

In June 2011, the Department of Respiratory and Critical Care Medicine established the "Respiratory Endoscopy Center". At present, the department is equipped with one Olympus BF290 high-definition electronic bronchoscope and image processing system, one BF260 diagnostic bronchoscope, two BF1T260 therapeutic bronchoscopes, one BF-F260 fluorescent bronchoscope, one P60 portable bedside bronchoscope system, one LTF240 medical thoracoscope, one Fuji EBUS respiratory endoscopic ultrasound system, one high-frequency jet ventilator, one dual frequency laser treatment, one Pentax 1970k electronic bronchoscope and endoscopic image processing system, one Elbo multifunctional cryotherapy instrument, one argon electrotome workstation for respiratory endoscopy, one Pentax 1970k fiber electronic bronchoscope, one Storz rigid bronchoscope equipment and two Sony endoscopic image processing system.

After several years of development, the department has carried out routine bronchoscopy, medical thoracoscopy, fluorescence bronchoscopy, and has developed mature rigid bronchoscopy, argon plasma coagulation, cryosurgery, endoscopic endotracheal tumor resection, bronchial artery infusion chemotherapy, TBNA, ultrasound-guided bronchoscopy needle aspiration biopsy (EBUS-TBNA), bronchoalveolar lavage, bronchial balloon dilation, cryo-lung biopsy and other respiratory endoscopic diagnostic techniques. At the same time, the department has successively carried out high-pressure balloon dilatation in the treatment of airway stenosis, argon under rigid bronchoscope, cryotherapy, electrocoagulation, radiofrequency ablation, photodynamic therapy, metal and silicone stent implantation and other endoscopic treatment technologies, which significantly improved the diagnosis rate of patients with respiratory endoscopy, and made timely and effective diagnosis and treatment of patients with airway diseases.


Pulmonary Function Clinic

  The pulmonary function clinic is responsible for the pulmonary function examination tasks in the outpatient, inpatient and physical examination centers of the whole hospital. The department has advanced equipment, comprehensive testing items, and non-stop diagnosis during holidays, which provides a strong guarantee for the diagnosis and treatment of respiratory diseases. The department currently has a total of 4 professional and technical personnel, all of whom have participated in the standardized lung function training sponsored by the China Pulmonary Function Alliance and obtained the standardized lung function training certificate. One of the attending physicians studied in the Pulmonary Function Room of Zhongshan Hospital Affiliated to Fudan University for half a year in 2014, and one attended the Pulmonary Function Room of China-Japan Friendship Hospital for three months in 2019, and accumulated rich experience.

The department is equipped with a number of internationally advanced large-scale lung function testers, including two German Jaeger Pulmonary Function Testers (which can also be used as lung ventilation function and lung diffusion function, and equipped with body mapping box, pulse oscillation, excitation test and other modules) , one Japan Jieste lung function tester, one Germany Jaeger cardiopulmonary exercise test system.

The current projects in the lung function clinic include: pulmonary ventilation function test, bronchial dilation test, bronchial provocation test, lung diffusion function test, and exercise cardiopulmonary function test. The nitric oxide breath test project introduced in 2012 further improves the basis for diagnosis and treatment of patients with bronchial asthma, chronic cough, and COPD and medication guidance.


Respiratory laboratory

  The Department of Respiratory and Critical Care Medicine is equipped with a leading respiratory laboratory and respiratory microbiology laboratory in the province. In accordance with the requirements of the national strategic deployment and the construction plan of our hospital’s regional medical center and the Institute of Respiratory Diseases, the laboratory focuses on the diagnosis, treatment and prevention of common and harmful respiratory diseases as the main direction, and applies basic research as well as “clinical-basic-clinical” translational medicine, with the goal of improving the level of respiratory disease prevention and diagnosis and treatment in the region. It conducts researches on the diagnosis and treatment of respiratory diseases and is a respiratory laboratory with regional respiratory professional research representative capabilities.

The animal laboratory raises SPF rats and mice in accordance with the barrier system constructed and managed by the national standard. The room is also equipped with independent ventilation cages (IVC) for rats and mice for the breeding of laboratory animals that require a very strict microbial environment, and related autoclaving and Sterilized facilities and equipment; animal experiments are not only equipped with basic ventilators, anesthetics, shadowless lamps and other basic instruments, but also professional equipment for respiratory research, a comprehensive monitoring system for laboratory animal respiratory metabolism and various equipment for preparing respiratory research animal models. This platform can fully meet the needs of experimental animal respiration research.

The clinical microbiology laboratory of the hospital is equipped with world-leading technology instruments and equipment, such as the German Bruker MicroflexLT/SH automatic rapid biological mass spectrometry detection system, the French Mérieux vitek 2, the German Siemens WalkAway 96plus bacteria identification and drug sensitivity tester, the Mérieux Bact/Alert3D, the American BD company FX2000 automatic blood culture instrument, the ABI VIIA7 real-time fluorescent quantitative PCR amplification instrument, the Roche Cobas AmpliPrcep automatic nucleic acid detection system.



As the affiliated hospital of Shandong First Medical University, teaching is an important part of discipline construction and development. The department undertakes clinical teaching work for undergraduates, postgraduates, and doctoral students all year round, as well as standardized training for national residents, PCCM specialization and single training base. The average annual training is more than 300 medical students and 150 resident doctors. It undertook the editor-in-chief of two textbooks planned by the Ministry of Health, and participated in the compilation of one textbook planned by the Ministry of Health.

From 2014 to 2020, the department held seven consecutive Qianfoshan Breathing Summit Forum in Shandong Province, and currently undertakes one national continuing education project and three provincial continuing education projects.


Scientific research

In recent years, the discipline has undertaken 8 national, provincial and ministerial-level scientific research projects, including five projects from the Natural Science Foundation of Shandong Province and one project from the Shandong Medical and Health Technology Development Plan. It has successively won one second prize of the Ministry of Education for Science and Technology Progress and one first prize of the Municipal Science and Technology Progress Award. Published 108 papers in academic journals at home and abroad, including 58 SCI papers, 75 core journal papers, 42 other papers, 3 publications; 2 patents; 1 international advanced scientific research achievement. There are 16 people in the department serving as deputy directors and committee members of national and provincial academic organizations.


Medical environment

The general ward of the department is equipped with single, double and multi-person rooms. The ward is spacious, warm and comfortable. It is a standardized nursing model department in Shandong Province. The rescue room is equipped with advanced equipment, several invasive and non-invasive ventilators, ECG monitors, complete facilities, and orderly management. The consultation room is standard, clean and bright. It can provide comprehensive and high-quality services to patients from all over the country and the province.

Respiratory department diagnoses and treats a large number of difficult and critically ill patients with respiratory system every year. At present, the subject has been based on the regional medical center of Shandong Province and supported by Shandong Institute of respiratory diseases. The “specialty alliance of respiratory and critical care medicine of the First Affiliated Hospital of Shandong First Medical University” has been established, with 92 alliance units. The aim is to focus on the standardized construction of the respiratory profession in Shandong Province, improve the level of medical technology in the region, strengthen the quality of medical services, strengthen the training of respiratory talents, and guide the development of various respiratory interventional treatments and the treatment of difficult and critical patients.

Relying on the national respiratory disease promotion project and Shandong Institute of respiratory diseases, with the support of the National Health Commission, the provincial government, Shandong First Medical University, and the hospital, based on the established characteristic specialty of the respiratory system and advanced technology, Respiratory Department of The First Affiliated Hospital of Shandong First Medical University has formed a systematic therapeutic mode and characteristic expert team for complex and rare respiratory diseases treatment. Currently, the Shandong Institute of Respiratory Diseases is actively applying for the National Regional Respiratory Medical Center. In the future, we will take the national respiratory regional medical center as an opportunity, take Shandong Institute of respiratory diseases as the foundation, take the diagnosis and treatment of complex and rare respiratory diseases as the core, comprehensively expand the advantages of respiratory specialty, and escort the people's respiratory health!